Kai'Sa

Strengths

Try to catch enemy carries alone to burst them with Icathian Rain.
Work with your teammates to set up your Ultimate and optimize damage with your passive.
Make sure to buy items that will evolve at least 1 or 2 of your spells.

Passive · Second Skin — Kai'Sa's basic attacks stack Plasma, dealing increasing bonus magic damage. Allies' immobilizing effects help stack Plasma. Additionally, Kai'Sa's item purchases upgrade her basic spells to have more powerful properties.
Q · Icathian Rain — Kai'Sa shoots a swarm of missiles that seek out nearby targets. Living Weapon: Icathian Rain is upgraded to shoot more missiles.
W · Void Seeker — Kai'Sa shoots a long range missile, marking enemies with her passive. Living Weapon: Void Seeker is upgraded to apply more passive marks and reduce cooldown on champion hit.
E · Supercharge — Kai'Sa briefly increases her Move Speed, then increases her Attack Speed. Living Weapon: Supercharge is upgraded to briefly grant Invisibility.
Ultimate · Killer Instinct — Kai'Sa dashes near an enemy champion.

A suggested 5-lane lineup built around Kai'Sa, based on hero partnerships and role synergy — not win rate.