Vladimir

Strengths

Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.

Passive · Crimson Pact — Every 30 points of bonus Health gives Vladimir 1 Ability Power and every 1 point of Ability Power gives Vladimir 1.6 bonus Health (does not stack with itself).
Q · Transfusion — Vladimir steals life from the target enemy. When Vladimir's resource is full, Transfusion will benefit from massively increased damage and healing for a brief time.
W · Sanguine Pool — Vladimir sinks into a pool of blood, becoming untargetable for 2 seconds. Additionally, enemies on the pool are slowed and Vladimir siphons life from them.
E · Tides of Blood — Vladimir pays his own health to charge up a reservoir of blood which, when released, deals damage in the area around him but can be blocked by enemy units.
Ultimate · Hemoplague — Vladimir infects an area with a virulent plague. Affected enemies take increased damage for the duration. After a few seconds, Hemoplague deals magic damage to infected enemies and heals Vladimir for each enemy Champion hit.

A suggested 5-lane lineup built around Vladimir, based on hero partnerships and role synergy — not win rate.